Sotoxen 120mg (Sotorasib) is a new drug that has been recently approved by the FDA for the treatment of advanced lung cancer. It is designed to target a specific genetic mutation called KRAS G12C, which is found in about 13% of non-small cell lung cancer (NSCLC) patients. This genetic mutation has long been considered “undruggable,” meaning that no drug has been able to target it effectively. However, Sotoxen 120mg (Sotorasib) has shown remarkable success in clinical trials and is now being hailed as a game-changer in the fight against lung cancer.

What is Sotoxen 120mg (Sotorasib)?

Is a targeted therapy drug that is designed to block the action of KRAS G12C, a genetic mutation that is often found in patients with NSCLC. It is an oral medication that is taken once a day and is available in a 120mg dose.

How does it work?

Sotoxen 120mg works by inhibiting the activity of KRAS G12C, which is a protein that is involved in the development and progression of cancer. By blocking this protein, Sotoxen 120mg (Sotorasib) can help to slow down the growth and spread of cancer cells, ultimately leading to tumor shrinkage and improved patient outcomes.

What is advanced lung cancer?

Advanced lung cancer is a type of cancer that has spread beyond the lungs to other parts of the body. It is often difficult to treat and can be very aggressive, with a poor prognosis for patients. Advanced lung cancer is typically diagnosed at a later stage, when the cancer has already metastasized to other organs.

Why is Sotoxen 120mg (Sotorasib) a revolutionary treatment?

It is a revolutionary treatment because it targets a previously “undruggable” genetic mutation that is found in a significant percentage of NSCLC patients. By blocking this mutation, Sotoxen 120mg (Sotorasib) can help to slow down the growth and spread of cancer cells, ultimately leading to improved patient outcomes. It is the first drug to target KRAS G12C, and it has shown remarkable success in clinical trials, making it a promising new option for patients with advanced lung cancer.

Understanding 

It works by binding to KRAS G12C, which is a protein that is involved in the development and progression of cancer. By binding to this protein, Sotoxen 120mg (Sotorasib) can prevent it from carrying out its normal functions, ultimately leading to tumor shrinkage and improved patient outcomes.

Efficacy 

The efficacy of Sotoxen 120mg (Sotorasib) has been demonstrated in clinical trials, including the CodeBreaK 100 trial. In this trial, patients with advanced NSCLC who had the KRAS G12C mutation were given Sotoxen 120mg (Sotorasib) once a day. The results showed an overall response rate of 37.1%, with a disease control rate of 80.6%. 

Safety and side effects 

Like all drugs, Sotoxen 120mg (Sotorasib) can cause side effects. The most common side effects observed in clinical trials include diarrhea, nausea, fatigue, and musculoskeletal pain. However, these side effects were generally mild to moderate in severity and could be managed with supportive care. Serious adverse events were rare, and no patients discontinued treatment due to side effects.

Dosage and administration 

Sotoxen 120mg (Sotorasib) is an oral medication that is taken once a day with or without food. It is important to take the medication exactly as prescribed by your healthcare provider, and to not miss any doses. Your healthcare provider will monitor your response to the medication and may adjust your dosage as needed.

Clinical Trials

Overview of the CodeBreaK 100 trial

The CodeBreaK 100 trial was a phase II clinical trial that evaluated the efficacy and safety of Sotoxen 120mg (Sotorasib) in patients with advanced NSCLC who had the KRAS G12C mutation. The trial included 126 patients who were treated with Sotoxen 120mg (Sotorasib) once a day.

Results of the CodeBreaK 100 trial

The results of the CodeBreaK 100 trial showed that Sotoxen 120mg (Sotorasib) had a 37.1% overall response rate and an 80.6% disease control rate. The median duration of response was 10 months, and the median progression-free survival was 6.8 months. These results were significant, as there are currently no other effective treatments for patients with advanced NSCLC who have the KRAS G12C mutation.

Comparison with other treatments

Sotoxen 120mg (Sotorasib) has shown superior efficacy compared to other treatments for advanced NSCLC that have the KRAS G12C mutation, such as chemotherapy and immunotherapy. In addition, Sotoxen 120mg (Sotorasib) has a more favorable side effect profile than these other treatments, making it a promising new option for patients.

Future directions for research 

Research on Sotoxen 120mg (Sotorasib) is ongoing, and there are currently several clinical trials underway to further evaluate its efficacy and safety. In addition, researchers are exploring the potential use of Sotoxen 120mg (Sotorasib) in other types of cancer that have the KRAS G12C mutation.

Patient Experience

Real-life patient stories 

Many patients who have received Sotoxen 120mg (Sotorasib) have reported positive experiences. For example, one patient reported that the drug had helped to shrink their tumors and had improved their quality of life. Other patients have reported fewer side effects with Sotoxen 120mg (Sotorasib) compared to other treatments they had previously received.

Benefits and limitations from a patient perspective

The benefits of Sotoxen 120mg (Sotorasib) from a patient perspective include its efficacy in treating advanced NSCLC with the KRAS G12C mutation, as well as its more favorable side effect profile compared to other treatments. The limitations of Sotoxen 120mg (Sotorasib) from a patient perspective include its cost, as it may not be covered by all insurance plans and may be expensive for some patients.

Support resources for patients 

There are many support resources available for patients who are taking Sotoxen 120mg (Sotorasib), including patient support programs, financial assistance programs, and educational resources. These resources can help patients better understand their treatment and manage any side effects or challenges that may arise.

Availability

BD anticancer drug store is the worldwide Sotoxen 120mg supplier in Bangladesh. Feel free and contact me via whatsapp +8801936974704 today. 

 

How much does Osimert cost? Where are the drugs sold? Does it have any side effects? These are all issues of concern to patients about Osimert. Knowing the information about this drug will help patients determine if they are suitable or not and in what dosage.

What is Osimert? – Find out what you need to know about this drug

Osimert is a brand name drug researched and manufactured by Everest Pharmaceuticals Ltd., of Bangladesh. This brand-name drug is used to treat lung disease through inhibition of kinases, and slows and stops the growth of cancer cells. This drug has been trusted and used in many countries around the world. Including Vietnam. In our country, the drug Osimert has been tested by regulatory authorities for quality and safety before being granted a license for widespread circulation.

• Brand Name: Osimert
• Category: Anti-cancer drugs
• Dosage form: Tablets
• Content: 80mg
• Packaging: Bottle of 30 tablets

Ingredient

In each Osimert oral tablet contains:

• Active ingredient: Osimertinib mesylate 80mg
• Excipients: Mannitol, Microcrystalline Cellulose, Hydroxpropyl cellulose less substituted and Sodium stearyl fumarate,… just enough for 1 tablet

Uses

The active ingredient osimertinib has the ability to inhibit epidermal growth factor receptor (EGFR) kinase and irreversibly bind to certain mutated forms of EGFR at low concentrations. inhibit the growth of cancer cells. 

Indications and contraindications

Osimert is indicated for the treatment of patients (over 18 years of age) with metastatic non-small cell lung cancer with a T790M mutation in the EGFR epidermal growth factor receptor gene. In addition, Osimert is also indicated for other cases:

• 3rd generation lung cancer
• The patient is resistant to some previous drugs

Osimert is contraindicated for use in the following subjects:

• Are allergic or hypersensitive to some of the ingredients in the medicine
• Children under 18
• Women who are pregnant and breast-feeding can harm the unborn baby and young children
• Patient with liver disease

How is Osimer used?

• Because Osimert is in the form of tablets, it is recommended that patients take 1 tablet per day. Drink only once a day.
• Take the medicine until the disease progresses.
• The recommended dose is 80mg/day. If you want to change your dose, you need to talk to your doctor.
• Take the medicine with a large glass of water to increase absorption.
• Osimert is taken after meals.
• If you miss a dose, take it as soon as you remember. If you miss a dose by more than 12 hours, skip the dose and continue using your usual schedule.

Notes when using Osimert to treat lung cancer

During the use of Osimert, patients should note a number of issues as follows:

Careful

• Take medication as directed by a specialist.
• Osimert should not be used for random purposes. To be used only with expert permission.
• If you are a woman, do not use Osimert if you are pregnant. On the other hand, do not use the drug if you intend to become pregnant because some ingredients in the drug will affect the growth and formation of the fetus.
• Osimert can reduce the body’s immunity to infections, so pay attention to patients with severe infections or immunocompromised people with bruising, bleeding, etc.
• Patients with a history of cardiovascular disease should exercise caution before use.
• Use Osimert medicine with expiry date, without defective packaging.

 

Side effects

Some common side effects of Osimert are:

• Anorexia, mouth sores
• Diarrhea
• Tired body
• Dry skin
• Skin rash
• Skin discoloration, infection
• Having problems with fingernails and toenails

Most of these common side effects can be relieved within a few hours and rarely turn into a severe stage. Therefore, users are not too worried when encountering. However, if you experience the following symptoms, you should immediately stop using the drug and seek medical help:

• Shortness of breath even with mild exertion
• Fast heart beat
• Fast weight gain
• New or worsening lung symptoms: chest pain, sudden irritability, dry cough, wheezing, eye problems (eye pain, vision changes, tearing, increased sensitivity to light, etc.) …

Drug interactions

Osimert has the potential to interact with a number of other medications. If used incorrectly, it can reduce the effectiveness of the drug and increase side effects. Therefore, patients need to talk to their doctor before using. Especially the following drugs:

• Strong inducer
• Breast cancer-fighting protein
• Substrate P-glycoprotein

In addition, Osimert drug may interact with some foods such as food, alcohol, coffee, tobacco, etc. Therefore, when used in combination, it is necessary to discuss with your doctor before use.

With the information shared in the article, readers have wondered how much Osimert drug costs. For more information, please talk to your doctor or pharmacist directly for assistance.

Where To Buy Osimert 80mg?

Osimert 80mg is available at BD anticancer drug store, and we do worldwide shipping at low cost.